Acromegaly

Ko te Acromegaly he ahuatanga e nui rawa ai te homone tipu (GH) o te tinana.

Ko te Acromegaly he ahuatanga onge. I puta mai i te wa e nui rawa ai te homone tupu o te pituitary gland. Ko te repe pituitary he repe endocrine iti ka piri ki raro o te roro. Ka whakahaerehia, ka hanga, ka whakaputa i nga homoni maha, tae atu ki te homoni tipu.

I te nuinga o te wa ko te puku kore (mate) o te repe pituitary ka tukuna he nui rawa te homone tipu. I etahi wa, ka taea te tuku i nga pukupuku pituitary.

I roto i nga tamariki, ko te nui o te GH ka puta ai te gigantism kaore i te acromegaly.

Ko nga tohu o te haehae e whai ake nei:

• Kakara tinana
• Te toto i roto i te turanga
• Hinengaro huringa Carpal
• Te whakaheke i te kaha o te uaua (ngoikore)
• Te whakaheke i te tirohanga taiao
• He ngoikore ngawari
• Te teitei teitei (ka tiimata ana te mahi GH nui i te wa o te tamarikitanga)
• Te werawera nui
• Ānini
• Whakanuia te ngakau, e ngoikore ai ranei
• Urutapu
• Te mamae o te kauae
• Te mamae o te hononga, te korenga o te nekehanga o te hononga, te pupuhi o nga waahi ngutu huri noa i te hononga
• Nga koiwi nui o te kanohi, te kauae me te arero nui, he niho tuuturu
• Waewae nui (huri i te rahi o te hu), ringaringa nui (whakarereke i te mowhiti me te rahi karapu)
• Repe nui i roto i te kiri (repe sebaceous) meinga kiri kiri, matotoru o te kiri, tohu kiri (tupu)
• Waatea moe
• Whanui nga maihao, maiharo ranei, me te pupuhi, ka whero, ka mamae

Ko etahi atu tohu ka pa pea ki tenei mate:

• Koroni polyps
• Te nui o te tipu o nga makawe wahine (hirsutism)
• Te toto toto tiketike
• Momo mate huka 2
• Whakanui thyroid
• Taumaha taumaha

Ka whakamātautau te Kaitiaki Hauora i te tinana, ka paatai ​​mo o tohu.

Ko nga whakamatau e whai ake nei ka whakahaua kia whakatutukihia te taatai ​​o te koromegaly me te tirotiro he aha nga raru.

• Te kūhuka o te toto
• Te tipu tupu me te whakamatauhia te pehi i te himoni tupu
• Ko te tipu tipu penei i te Insulin-1 (IGF-1)
• Prolactin
• Raina-hihi
• MRI o te roro, tae atu ki te repe pituitary
• Echocardiogram
• Koroneihana
• Akoranga moe

Ka whakahaua etahi atu whakamatautau kia tirohia mena kei te pai te mahi o te toenga o te repe pituitary.

Ko te taahiraa hei tango i te puku pituitary e mate ana i tenei ahuatanga he maha nga waa ka whakatika i te GH rereke. I etahi wa, he nui rawa te tumo kia nekehia katoatia ana kaore te rongoa o te mate i te rongoa. I tenei waa, ka taea te whakamahi i nga rongoa me te radiation (radiotherapy) ki te hamani i te whakaorotanga.

Ko etahi taangata he pukupuku tera he uaua rawa atu ki te tango ma te pokanga e tukuna ana ki nga rongoa kaore i te pokanga. Ko enei rongoa ka aukati i te mahi GH mai i te repe pituitary gland hei aarai ranei i te mahi a te GH ki etahi atu waahanga o te tinana.

Whai muri i te whakamaimoa, me haere tonu koe ki te tirotiro i to kaiwhakarato kia tino mohio kei te pai te mahi o te repe pituitary, me te kore e hoki mai ano te acromegaly. E taunaki ana i nga arotake-a-tau.

Ma enei rauemi pea e whakaatu etahi korero mo te haurangi:

• National Institute of Diabetes and Digestive and Kidney Diseases - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• National Organization for Rare Raruraru - rarediseases.org/rare-diseases/acromegaly

He angitu te taatai ​​pituitary i te nuinga o nga taangata, i te rahinga o te puku me te wheako o te neurosurgeon me nga pukupuku pituitary.

Ki te kore he maimoatanga, ka kino rawa atu nga tohu. Ko nga ahuatanga penei i te toto toto nui, te mate huka, me te mate manawa ka puta mai.

Karangahia to kaiwhakarato mena:

• Kei i a koe nga tohu o te haehae
• Kaore e pai ake o tohu ki te rongoa

Kaore e taea te aukati i te Acromegaly. Ma te maimoatanga wawe pea e aukati te mate kia kino ake, kia kore ai e raru.

Somatotroph adenoma; Te nui o te homoni tupu; Te whakanui i te homoni e huna ana i te adenoma pituitary; Rapa nunui (i te tamarikitanga)

• Repe repe Endocrine

Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: he aratohu mahi haumanu a te hapori endocrine. J Clin Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Nga mate endocrine me nga mate pukupuku ngakau. I roto i: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. He Mate Ngakau a Braunwald: He Pukapuka Kupu mo te Maimoatanga Mate Mate. 10 o nga ra. Philadelphia, PA: Elsevier Saunders; 2015: chap 81.

Melmed S. Acromegaly. I roto i: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Pakeke me te Pediatric. Ed 7. Philadelphia, PA: Elsevier Saunders; 2016: chap 12.