Prothrombin ngoikoretanga

Ko te ngoikoretanga o te Prothrombin he raru ka pa mai i te korenga o te pūmua i roto i te toto e kiia nei ko te prothrombin. Ka puta he raru ki te whakaheke toto (coagulation). Ko te Prrombrombin e mohiotia ana ko te tauwehe II (tauwehe tuarua).

Ka toto ana koe, ka puta etahi urupare ki te tinana ka awhina i te whakaheke toto. Ko tenei mahinga e kiia ana ko te cascade coagulation. Kei roto hoki i nga pūmua motuhake e kiia nei ko te koohuru, he kohinga ranei. Akene he nui ake to tuponotanga ki te whakaheke toto mena ka ngaro tetahi, neke atu ranei o enei ahuatanga, kaore ranei e mahi peera me tera.

Ko te Prrombrombin, ko te take II ranei, tetahi o nga mea whakatooa. Ko te ngoikoretanga Prothrombin ka rere i roto i nga whanau (he mea tuku iho) a he tino onge. Ko nga maatua e rua me whai ira ki te tuku i te mate ki a raatau tamariki. Ko te hitori o te whanau he mate toto ka waiho hei take morearea.

Ko te ngoikoretanga Prothrombin ka taea ano ma tetahi atu ahuatanga, whakamahi ranei i etahi rongoa. Ka kiia tenei ko te ngoikoretanga o te prothrombin kua riro. Na te:

• Te kore o te huaora K (ka whanau etahi peepi me te kore o te huaora K)
• Te mate ate tino
• Te whakamahinga o nga rongoa hei aukati i te koroke (anticoagulants penei i te warfarin)

Kei roto i nga tohu nga tohu e whai ake nei:

• Te heke toto i muri i te whanautanga
• He nui te whakaheke toto
• Mate toto i muri o te pokanga
• Te toto i muri o te aituā
• Ngawari te maru
• Nosebleeds e kore e mutu ngawari
• Te toto taura toto i muri o te whanautanga

Ko nga whakamatautau ka taea te mahi:

• Take II whakamātautau
• Wahanga thromboplastin wahanga
• Te wa Prothrombin (PT)
• Te rangahau whakaranu (he whakamatautau PTT motuhake hei whakaū i te ngoikoretanga o te prothrombin)

Ka taea te whakahaere i te whakaheke toto ma te whakauru i te weronga (IV) ki te whaowhia o te waipiro, ki nga kukuti ranei o nga take tauwehe. Mena ka hapa koe i te huaora K, ka taea e koe te tango i tenei huaora ma te waha, ma roto i nga werohanga i raro i te kiri, ma roto ranei i te uaua (ka puta te mate).

Mena he mate toto koe, kia kaha ki te:

• Korerohia atu ki o kaiwhakarato hauora i mua i a koe tetahi momo whakahaere, tae atu ki te pokanga me te mahi niho.
• Korerohia atu ki o mema o te whanau na te mea he peera tonu o raatau engari kaore ano kia mohio.

Ma enei rauemi e whakarato etahi atu korero mo te ngoikoretanga o te Take VII:

• National Hemophilia Foundation: etahi ngoikoretanga take - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• NIH Genetic and Rare Diseases Information Center - rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

He pai te mutunga me te maimoatanga tika.

Ko te ngoikoretanga o te prothrombin kua riro hei oranga mo te wa katoa.

Ko te tirohanga mo te whiwhi ngoikoretanga o te prothrombin kei i te kaupapa. Mena na te mate ate i puta, ko te mutunga ka pa ki te pai o te whakaora i to mate ate. Ko te tango i nga taapiringa huaora K ka rongoa i te ngoikoretanga o te huaora K.

Ka kaha te heke o te toto i roto i nga okana.

Me tere te whakaora urupare mena kaore koe i te marama, kua ngaro ranei i te wa roa, ki te kore ranei e taea e koe te aukati i te whakaheke toto.

Kaore he aukati e mohiotia ana mo te ngoikoretanga o te prothrombin. Mena ko te kore o te huaora K te take, ma te whakamahi i te huaora K e awhina ai.

Hypoprothrombinemia; Take II ngoikoretanga; Dysprothrombinemia

• Te whakaheke toto
• Pakihi toto

Gailani D, Wheeler AP, Neff AT. Nga ngoikoretanga o te tauwehenga onge. I roto i: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Maatauranga Maatauranga me te Mahi. Ed 7. Philadelphia, PA: Elsevier; 2018: chap 137.

Hall JE. Hemostasis me te toto toto. I roto i: Hall JE, ed. Guyton me te Pukapuka Pukapuka a Hall mo te Hauora Hauora. 13th ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 37.

Ragni MV. Nga mate hemorrhagic: nga ngoikoretanga o te waahanga I roto i: Goldman L, Schafer AI, eds. Te rongoa Goldman-Cecil. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 174.