Tuhinga o mua

Toka Te Manawa

• He aha te whakamātautau ira a BRCA?
• Hei aha te whakamahi?
• He aha i hiahia ai ahau ki tetahi whakamatautau ira ira BRCA?
• Ka ahatia i te wa o te whakamatautau ira a BRCA?
• Me mahi e au tetahi mea hei whakareri mo te whakamatautau?
• He raru pea mo te whakamatautau?
• He aha te tikanga o nga hua?
• He mea ano me mohio au mo te whakamatautau ira a BRCA?
• Tohutoro

He aha te whakamātautau ira a BRCA?

Ko te whakamatautau ira a BRCA e rapu ana i nga whakarereketanga, e mohiotia ana ko te huringa, i roto i nga ira e kiia ana ko BRCA1 me BRCA2. Ko nga ira nga waahanga o te DNA i tukuna mai i to whaea me to papa. Kei a ratau nga korero e whakatau ana i o ahuatanga motuhake, penei i te teitei me te tae o te karu. Kei a Genes ano te kawenga mo etahi tikanga hauora. Ko te BRCA1 me te BRCA2 he ira e tiaki ana i nga pūtau ma te hanga pūmua hei aukati i te peke o nga pukupuku.

Ko te rereketanga o te ira BRCA1, o te BRCA2 ranei ka raru te pūtau ka mate pea ki te mate pukupuku. Ko nga waahine he ira BRCA mutate te mea nui ake te mate kei mate i te u, te mate pukupuku ovarian ranei. Ko nga taane me te ira BRCA mutate ka nui ake te tuponotanga ki te whiwhi i te mate pukupuku o te u, te repeure ranei. Kaore nga tangata katoa ka whiwhi i te rereketanga BRCA1, BRCA2 ranei, ka pangia e te mate pukupuku. Ko etahi atu take, tae atu ki to ahua noho me to taiao, ka raru pea to mate pukupuku.

Mena ka mohio koe he rereketanga to BRCA koe, ka taea pea e koe te whai i nga huarahi hei tiaki i to hauora.

Ko etahi ingoa: BRCA ira whakamātautau, BRCA ira 1, BRCA ira 2, ira whakaraerae mate pukupuku uma1, ira whakaraerae mate pukupuku uma 2

Hei aha te whakamahi?

Ka whakamahia tenei whakamatautau kia mohio ai kei te huri koe i te ira ira BRCA1, te BRCA2 ranei. Ma te rereketanga o te ira BRCA e piki ake ai te mate o te mate pukupuku.

He aha i hiahia ai ahau ki tetahi whakamatautau ira ira BRCA?

Ko te whakamatautau BRCA kaore i te taunakitia mo te nuinga o te iwi. He uaua te rereketanga o te ira BRCA, ka pa ki te 0.2 orau noa iho o te taupori U.S. Engari ka hiahia pea koe ki tenei whakamatautau mena ka whakaarohia e koe ka nui ake te tuponotanga ki te whakarerekehia e koe. Ka nui ake pea to rereketanga BRCA mena:

• I mate koe i te mate pukupuku uma ranei i kitea i mua i te 50 tau
• I mate pukupuku koe i te u ranei i nga uma e rua
• Kua pangia e te mate pukupuku uma me te pukupuku ovarian ranei?
• Kia kotahi neke atu ranei nga mema o te whanau ka pa te mate pukupuku o te u
• He whanaunga taane me te mate pukupuku o te u
• Me whakapae tetahi o ou whanaunga he whakarereke BRCA
• No Ashkenazi (Eastern Europe) nga tupuna o nga Hurai. Ko nga rereketanga BRCA e tino kitea ana i roto i tenei roopu ka whakatauritehia ki te taupori whanui. Ko nga rereketanga BRCA he mea nui ake mo nga taangata mai i etahi atu waahanga o Uropi, tae atu ki, Tiorangi, Norewi me Denmark.

Ka ahatia i te wa o te whakamatautau ira a BRCA?

Ka tangohia e tetahi tohunga ngaio hauora tetahi tauira toto mai i te uaua i roto i to ringa, ma te whakamahi i te ngira iti. Whai muri i te kuhunga o te ngira, ka kohia he toto iti ki roto i te ipuipu, ipu ranei. Akene he iti to ngau ka puta te ngira ki waho ka puta atu ranei. Ko te tikanga ka iti ake i te rima meneti tenei.

Me mahi e au tetahi mea hei whakareri mo te whakamatautau?

Kaore e hiahiatia he whakaritenga motuhake mo te whakamatautau BRCA. Engari akene kei te hiahia koe ki te hui tahi me tetahi kaitohutohu o te iranga kia kite koe mena he tika te whakamatautau ki a koe. Ka korero pea to kaitohutohu ki a koe mo nga morearea me nga painga o te whakamatautau ira me nga hua rereke e taea ana.

Me whakaaro hoki koe ki te tiki tohutohu aa-ira i muri o to whakamatautau. Ka taea e to kaitohutohu te korero mo te paanga o o hua ki a koe me to whanau, i te taha hauora me te kare a roto.

He raru pea mo te whakamatautau?

He iti noa te tuponotanga ka tirohia o toto. Ka mamae pea koe, ka maru ranei koe i te waahi i maka ai te ngira, engari ko te nuinga o nga tohu ka tere wawe.

He aha te tikanga o nga hua?

Ko te nuinga o nga hua ka kiia he kino, kaore e tau, he pai ranei, me te tikanga ko enei e whai ake nei:

• He hua kino te tikanga kaore i kitea he rereketanga ira BRCA, engari ehara i te kii kaore koe e mate pukupuku.
• He hua kore te tikanga i kitea etahi momo rereketanga ira BRCA, engari akene kaore pea e hono atu ki te morearea o te mate pukupuku. Akene me nui ake nga whakamatautau me / te tirotiro ranei mena kaore i tino tau o hua.
• He hua pai te tikanga i kitea he hurihanga i te BRCA1, i te BRCA2 ranei. Ma enei rereketanga e kaha ai to mate ki te mate pukupuku. Engari kaore ko nga mea katoa e whakarereke ana te mate pukupuku.

He maha pea nga wiki ka tae ki o hua. Mena he paatai ​​taau e pa ana ki o hua, korero ki to kaiwhakarato hauora me / to kaitohutohu ira ranei.

Ako atu mo nga whakamatautau taiwhanga, awhe tohutoro, me te maarama ki nga hua.

He mea ano me mohio au mo te whakamatautau ira a BRCA?

Mena ka kitea i o kitenga he rereketanga ira BRCA koe, ka taea e koe te whai huarahi hei whakaiti i to mate pukupuku o te u. Kei roto i enei:

• Ko nga whakamatautau whakamatauhia he mate pukupuku i nga wa katoa, penei i te mammograms me te ultrasounds. He maama ake te rongoa o te mate pukupuku ka kitea ana i nga timatanga.
• Te tango i nga pire aukaha mo te wa iti. Ko te tango i nga pire aukaha mo te wa nui mo te rima tau kua whakaatuhia hei whakaiti i te tuponotanga o te mate pukupuku ovarian i etahi waahine he panoni ira ira BRCA. Ko te tango i nga pire neke atu i te rima tau ki te whakaiti i te mate pukupuku e kore e manakohia. Mena kei te tango koe i nga pire aukaha whanau i mua i to whakamatautau i te BRCA, korero atu ki to kaiwhakarato hauora e hia ou tau i to tiimata i te tango i nga pire me te roa o te wa. Ka taunahihia e ia mena ka haere tonu koe ki te tango.
• Te tango i nga rongoa whawhai-mate pukupuku. Ko etahi raau taero, penei i te tamoxifen, kua whakaatuhia hei whakaiti i te tuponotanga ki nga waahine he nui ake te mate pukupuku o te uma.
• Ma te pokanga, e mohiotia ana ko te mastectomy aukati, hei tango i nga kiko o te uma ora. Kua whakaatuhia te mastectomy aukati ki te whakaheke i te raru o te mate pukupuku pukupuku ka rite ki te 90 orau i roto i nga waahine he whakarereke ira ira BRCA. Engari he mahi nui tenei, he mea taunaki anake ma nga waahine he tino morearea pea mo te mate pukupuku.

Me korero koe ki to kaiwhakarato hauora kia kite he aha nga huarahi pai hei mahi maau.

Tohutoro

1. American Society of Clinical Oncology [Ipurangi]. American Society o Haumanu Oncology; 2005-2018. Te Umi Whakatuku me te Mate Mate Mate Ovarian; [cited 2018 Mar 19]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
2. Hinkle J, Cheever K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Test. 2nd Ed, Rama. Philadelphia: Wolters Kluwer Hauora, Lippincott Williams & Wilkins; c2014. Whakamatautau BRCA; 108 wh.
3. Nga Whakamatautau Reipa Aipurangi [Ipurangi]. Washington D.C .: American Association mo te Haumanu Haumanu; c2001–2018. BRCA Gene Mutation Testing [whakahoutia 2018 Hanu 15; whakahuahia 2018 Pepuere 23]; [tata ki te 2 nga mata]. Wātea mai i: https://labtestsonline.org/tests/brca-gene-mutation-testing
4. Mayo Clinic [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1998–2018. Whakamātautau ira BRCA mo te mate pukupuku mate pukupuku me te pukupuku ovarian; 2017 Tihema 30 [whakahua 2018 Pepuere 23]; [tata ki te 3 nga mata]. Wātea mai i: https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
5. Whakamaumaharatanga ki te Whare Korerotanga o Sloan Kettering Cancer [Ipurangi]. New York: Whakamaumahara ki te Whare Mate Mate a Sloan Kettering; c2018. BRCA1 me te BRCA2 Ira: Te morearea mo te Mate Mate Mate me te Ovarian [kua whakahuahia i te 2018 Pepuere 23]; [tata ki te 5 o nga mata]. Wātea mai i: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/brca1-brca2-genes-risk-breast-ovarian
6. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Nga Huringa BRCA: Te Mate Mate Mate me te Whakamatau Tohu [i whakahuahia i te 2018 Pepuere 23]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#q1
7. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Tikanga Mate Mate: huringa [whakahua 2018 Pepuere 23]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=mutation
8. National Heart, Lung, and Blood Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Nga Whakatautau Toto [cited 2018 Pepuere 23]; [tata ki te 3 nga mata]. Wātea mai i: https://www.nhlbi.nih.gov/health-topics/blood-tests
9. NIH U.S. National Library of Medicine: Genetics Home Tohunga [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. BRCA1 ira; 2018 Mar 13 [whakahua i te 2018 Maehe 18]; [tata ki te 3 nga mata]. Wātea mai i: https://ghr.nlm.nih.gov/gene/BRCA1#conditions
10. NIH U.S. National Library of Medicine: Genetics Home Tohunga [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. BRCA2 ira; 2018 Mar 13 [whakahua i te 2018 Maehe 18]; [tata ki te 3 nga mata]. Wātea mai i: https://ghr.nlm.nih.gov/gene/BRCA2#conditions
11. NIH U.S. National Library of Medicine: Genetics Home Tohunga [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. He aha te ira? 2018 Pepuere 20 [whakahua i te 2018 Pepuere 23]; [tata ki te 3 nga mata]. Wātea mai i: https://ghr.nlm.nih.gov/primer/basics/gene
12. Whare Wananga o Rochester Medical Center [Ipurangi]. Rochester (NY): Whare Wananga o Rochester Medical Center; c2018. Encyclopedia Hauora: BRCA [whakahua i te 2018 Pepuere 23]; [tata ki te 2 nga mata]. Wātea mai i: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=brca
13. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Mate Mate Mate (BRCA) Whakamatau Ira: Me Pehea Te Whakarite [whakahoutia 2017 Jun 8; whakahuahia 2018 Pepuere 23]; [tata ki te 5 o nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6465
14. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Mate Mate Mate (BRCA) Whakamatau Ira: Nga Hua [whakahoutia 2017 Jun 8; whakahuahia 2018 Pepuere 23]; [e 9 pea nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6469
15. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Mate Mate Mate (BRCA) Whakamatau Gene: Tirohanga Tirohanga [whakahoutia 2017 Jun 8; whakahuahia 2018 Pepuere 23]; [tata ki te 2 nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html
16. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Mate Mate Mate (BRCA) Whakamatau Ira: Te Take I Whakamutua Ai [whakahoutia 2017 Jun 8; whakahuahia 2018 Pepuere 23]; [e 4 pea nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu646

Ko nga korero kei tenei papaanga kaua e whakamahia hei whakakapi mo te tiaki ngaio ngaio, tohutohu ranei. Whakapa atu ki te kaiwhakarato hauora mena he paatai ​​taau mo to hauora.