TP53 Whakamatau Tohu

Toka Te Manawa

• He aha te whakamatautau ira ira TP53?
• Hei aha te whakamahi?
• He aha i hiahiatia ai e ahau he whakamatautau ira TP53?
• He aha te mahi i te wa o te whakamatautau ira ira TP53?
• Me mahi e au tetahi mea hei whakareri mo te whakamatautau?
• He raru pea mo te whakamatautau?
• He aha te tikanga o nga hua?
• He mea ano me mohio au mo te whakamatautau TP53?
• Tohutoro

He aha te whakamatautau ira ira TP53?

Ko te whakamatautau ira a TP53 e rapu ana i tetahi whakarereketanga, e mohiotia ana ko te hurihanga, i roto i te ira e kiia nei ko TP53 (tumo protein 53). Ko te ira te waahanga taketake o te whakapapa i heke iho mai i to whaea me to papa.

Ko TP53 he ira hei awhina i te tipu o nga puku. E mohiotia ana ko te pehanga puku. Ko te ira pehanga puku ka rite ki te taraiwa o te motuka. Ka waiho nga "frein" ki nga ruma, kia kore e tere te wehewehe. Mena he rereketanga to TP53, kaore pea e taea e te ira te whakahaere i te tipu o o kiri. Ko te tipu o te puoro kaore e taea te whakahaere ka pa te mate pukupuku.

Ka taea te tuku whakarereke TP53 mai i o matua, ka riro mai i muri mai i te taiao, mai i tetahi he ranei ka pa ki to tinana i te wa o te wehenga o te pūtau

• Ko te huringa TP53 tuku iho e mohiotia ana ko te Li-Fraumeni syndrome.
• Ko te mate Li-Fraumeni he ahuatanga tuponotanga ka taea te whakanui ake i etahi momo mate pukupuku.
• Ko enei mate pukupuku ko te mate pukupuku o te uma, te mate pukupuku o te wheua, te reukemata, me nga pukupuku pukupuku ngohengohe, e kiia ana ko nga sarcomas.

Whiwhi (e mohiotia ana ko somatic) TP53 huringa ka nui noa ake te kitea. Ko enei huringa i kitea i te haurua o nga keehi katoa o te mate pukupuku, me te tini o nga momo mate pukupuku.

Othertahi atu ingoa: TP53 wetewetenga wetewete, TP53 taatai ​​ira katoa, TP53 whakarereke somatic

Hei aha te whakamahi?

Ka whakamahia te whakamatautau hei rapu mo tetahi huringa TP53. Ehara ko te whakamatautau noa.I te nuinga o te waa ka tukuna ki nga taangata e pa ana ki te hitori o te whanau, nga tohu, te tohu mate pukupuku o mua ranei.

He aha i hiahiatia ai e ahau he whakamatautau ira TP53?

Akene me whai whakamatautau koe TP53 mena:

• Kua kitea koe i te mate pukupuku wheua kiri maeneene ranei i mua i te 45 tau
• Kua kitea koe i te mate pukupuku o te uma o mua-menopausal, he puku roro, leukemia, te mate pukupuku pukupuku ranei i mua i te tau 46
• Kua oti i a koe tetahi atu neke atu ranei o nga pukupuku i mua i te tau 46
• Ko tetahi, neke atu ranei o o mema o te whanau kua tohua he mate Li-Fraumeni me / i mate pukupuku koe i mua i te 45 tau

Koinei nga tohu kei a koe pea te whakarereketanga o te uri TP53.

Mena kua tohua koe he matepukupuku me te kore he hitori o te whanau o te mauiuitanga, ka tono pea to kaiwhakarato hauora tenei whakamatautau kia tirohia mena kei te huri tetahi TP53 i to mate pukupuku. Ma te mohio kei a koe te rereketanga ka taea e to kaiwhakarato te whakamahere maimoatanga me te matapae i te hua ka pa mai o to mate.

He aha te mahi i te wa o te whakamatautau ira ira TP53?

Ko te whakamatautau TP53 ka mahia i runga i te toto, te wheua wheua ranei.

Mena kei te whakamatautauria to toto, ka tangohia e tetahi tohunga ngaio hauora tetahi tauira toto mai i te uaua i roto i to ringa, ma te whakamahi i te ngira iti. Whai muri i te kuhunga o te ngira, ka kohia he toto iti ki roto i te ipuipu, ipu ranei. Akene he iti to ngau ka puta te ngira ki waho ka puta atu ranei. Ko te tikanga ka iti ake i te rima meneti tenei.

Mena kei te whakamatautauria e koe te wheua wheua, ko nga tikanga ka whai ake:

• Ka takoto koe i to taha, i to kopu ranei, ma tehea wheua e whakamahia hei whakamatautau. Ko te nuinga o nga whakamatautau wheua wheua ka tangohia i te wheua hope.
• Ka taupokina to tinana ki te kakahu, kia kitea noa ko te rohe huri noa i te waahi whakamatautau.
• Ka horoia te papaanga ki te rongoa antiseptic.
• Ka werohia koe i te rongoa koretake. Ka ngau pea.
• Kia koretake te rohe, ka tangohia e te kaiwhakaora hauora te tauira. Me takoto marie koe i nga wa o nga whakamatautau.
• Ka whakamahia e te kaitoha hauora tetahi taputapu motuhake ka huri ki roto ki te wheua hei tango i tetahi tauira kiko kiko wheua. Akene he pehanga kei runga i te papaanga i te wa e tangohia ana te tauira.
• Whai muri i te whakamātautau, ka hipokina e te kaiwhakaora hauora te papa ki te takai.
• Whakamaherehere kia tonoa koe e tetahi ki te kaainga, na te mea i tukuna ki a koe he kaiwhakamahu i mua o nga whakamatautau, kia hiamoe ai koe.

Me mahi e au tetahi mea hei whakareri mo te whakamatautau?

Te tikanga kaore e hiahiatia etahi whakaritenga motuhake mo te whakamatautau toto, wheua wheua ranei.

He raru pea mo te whakamatautau?

He iti noa te tuponotanga ka tirohia o toto. Ka mamae pea koe, ka maru ranei koe i te waahi i maka ai te ngira, engari ko te nuinga o nga tohu ka tere wawe.

Whai muri i te whakamatautau i te koiwi wheua, ka pakeke pea ka mamae koe i te waahi weronga ranei. Te tikanga ka haere tenei i roto i etahi ra. Ka tohu pea to kaiwhakarato hauora ki te whakahau ranei i tetahi kaitoha mamae ki te awhina.

He aha te tikanga o nga hua?

Mena kua tohua koe ki te mate Li-Fraumeni, na kaore te tikanga he mate pukupuku koe, engari he nui ake to tuponotanga i te nuinga o te iwi. Engari mena kei a koe te rereketanga, ka taea e koe te whai i nga huarahi hei whakaiti i to tuponotanga, penei i te:

• He maha ake nga tirotiro matepukupuku. He pai ake te whakaora i te mate pukupuku i te wa e kitea ana i nga timatanga.
• Te whakarereke i te ahua o te noho, penei i te kaha ki te korikori me te kai i te kai hauora
• Ko te Chemoprevention, ko te tango i etahi rongoa, huaora, me etahi atu mea ranei hei whakaiti i te tuponotanga kia whakaroa ranei i te whanaketanga o te mate pukupuku.
• Tango ana i te "morearea" te kiko

Ka rereke enei kaupae ki to hitori o to hauora me to whanau.

Mena he mate pukupuku koe me nga hua kua puta i te huringa TP53 kua riro (i kitea he rereketanga, engari kaore o whanau whiu mo te mate pukupuku, te mate Li-Fraumeni ranei), ka taea e to kaiwhakarato te whakamahi i nga korero hei awhina ki te matapae ka pehea te whanake o to mate me te arahi i to mate. maimoatanga

Ako atu mo nga whakamatautau taiwhanga, awhe tohutoro, me te maarama ki nga hua.

He mea ano me mohio au mo te whakamatautau TP53?

Mena kua tohua koe ki te whakaaro koe kei te puta koe i te mate Li-Fraumeni, ka pai pea te korero ki tetahi kaitohutohu a-ira. Ko te kaitohutohu a-ira he tohunga ngaio whakangungu i roto i te whakapapa me te whakamatau ira. Mena kaore ano kia whakamatautauria koe, ka taea e te kaitohutohu te awhina i a koe ki te maarama ki nga raru me nga painga o te whakamatautau. Mena kua whakamatautauria koe, ka taea e te kaitohutohu te awhina i a koe ki te maarama ki nga hua ka arahi ia koe ki te tautoko i nga ratonga me etahi atu rauemi.

Tohutoro

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2. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2020. Me pehea te whakamahi i nga Maimoatanga Tutuki ki te Hamani Mate Mate pukupuku; [whakahoutia 2019 Dec 27; whakahuahia 2020 Mei 13]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/targeted-therapy/what-is.html
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6. Li-Fraumeni Syndrome: LFSA Association [Ipurangi]. Holliston (MA): Li-Fraumeni Syndrome Association; c2018. He aha te LFS?: Li-Fraumeni Syndrome Association; [cited 2018 Jun 29]; [tata ki te 2 nga mata]. Wātea mai i: https://www.lfsassociation.org/what-is-lfs
7. Mayo Clinic [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1998–2018. Te koiora koiora wheua me te wawata: Tirohanga; 2018 Jan 12 [whakahua i te 2018 Jun 29]; [e 4 pea nga mata]. Wātea mai i: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic: Mayo Medical Laboratories [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1995–2018. ID Whakamatautau: P53CA: Hematologic Neoplasms, TP53 Somatic Mutation, DNA Whakatautau Whakatautau 4-9: Haumanu me te whakamaoritanga; [cited 2018 Jun 29]; [e 4 pea nga mata]. Wātea mai i: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62402
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Ko nga korero kei tenei papaanga kaua e whakamahia hei whakakapi mo te tiaki ngaio ngaio, tohutohu ranei. Whakapa atu ki te kaiwhakarato hauora mena he paatai ​​taau mo to hauora.