BCR ABL Whakamatau Whakamatau

Toka Te Manawa

• He aha te whakamātautau ira ira BCR-ABL?
• Hei aha te whakamahi?
• He aha i hiahiatia ai e ahau he whakamātautau ira ira BCR-ABL?
• Ka ahatia i te wa o te whakamatautau ira a BCR-ABL?
• Me mahi e au tetahi mea hei whakareri mo te whakamatautau?
• He raru pea mo te whakamatautau?
• He aha te tikanga o nga hua?
• He mea ano me mohio au mo te whakamatautau ira a BCR-ABL?
• Tohutoro

He aha te whakamātautau ira ira BCR-ABL?

He whakamātautau ira BCR-ABL e rapu ana i te whakarereke ira (whakarereke) i runga i te kiromaki motuhake.

Ko nga Chromosome nga waahanga o o punua kei roto i o ira. Ko nga ira nga waahanga o te DNA i tukuna mai i to whaea me to papa. Kei a ratau nga korero e whakatau ana i o ahuatanga motuhake, penei i te teitei me te tae o te karu.

Ko te tikanga he 46 nga chromosome a te tangata, ka tohatohahia kia 23 takirua, kei ia ruma. Ko tetahi o ia chromosome takirua mai i to whaea, ko tetahi atu takirua na to papa.

Ko te BCR-ABL he huringa ka hangaia e nga huinga e rua, e mohiotia ana ko BCR me te ABL. I etahi wa ka kiia he ira hono.

• Ko te ira BCR kei runga i te chromosome nama 22.
• Ko te ira ABL kei runga i te chromosome nama 9.
• Ka puta te hurihanga BCR-ABL ka pakaru nga waahanga o te ira BCR me te ABL ka huri i nga waahi.
• Ko te huringa ka kitea i runga i te chromosome 22, i te wahi i piri atu ai te waahanga chromosome 9 ki a ia ano.
• Ko te chromosome 22 kua whakahouhia ka kiia ko te chromosome o Philadelphia na te mea ko te taone nui i kitea tuatahihia ai e nga kairangahau.
• Ko te ira BCR-ABL ehara ko te momo huringa ka riro mai i o maatua. He momo hurihanga ohorere, te tikanga kaore koe i whanau mai. Ka whiwhi koe i muri mai i te ao.

Ko te ira BCR-ABL e whakaatuhia ana ki nga tuuroro e pa ana ki etahi momo leukemia, he mate pukupuku o te wheua wheua me nga toto toto ma. Ko te BCR-ABL e kitea ana i te nuinga o nga tuuroro katoa he momo leukemia e kiia ana ko te myeloid leukemia tawhito (CML). Ko tetahi ingoa mo te CML he roa myelogenous rewharewha. Ko nga ingoa e rua e pa ana ki te mate kotahi.

Ko te ira BCR-ABL ka kitea ano i etahi o nga tuuroro me te ahua o te rewharewha lymphoblastic whakapau (KATOA) me te uaua ki nga tuuroro me te kanisuka myelogenous nui (AML).

Ko etahi rongoa mate pukupuku e tino whaihua ana ki te whakaora i nga tuuroro leukemia me te rereketanga o te ira BCR-ABL. Ko enei rongoa he iti ake nga paanga kino i era atu maimoatanga mate pukupuku. Ko nga rongoa ano kaore e whai kiko ki te hamani i nga tuumomo kanisuka, i etahi atu mate pukupuku ranei.

Ko etahi atu ingoa: BCR-ABL1, BCR-ABL1 whakakotahitanga, Philadelphia chromosome

Hei aha te whakamahi?

Ko te whakamatautau BCR-ABL e whakamahia ana i nga wa katoa ki te tirotiro ki te whakakore ranei i te mate myemiaid leukemia (CML) he momo ake ranei o te kanisā lymphoblastic whakapau (KATOA) e kiia ana ko te Ph-positive KATOA Ph-positive te tikanga i kitea he chromosome Philadelphia. Kaore i te whakamahia te whakamatautau hei whakatau mate i etahi atu momo rewharewha.

Ka whakamahia pea te whakamatautau ki:

• Tirohia mena e whai hua ana te whakaora mate pukupuku.
• Tirohia mena kua whanakehia e te tuuroro te aukati i etahi maimoatanga. Ko te tikanga ko te maimoatanga i kaha ki te mahi kaore e mahi.

He aha i hiahiatia ai e ahau he whakamātautau ira ira BCR-ABL?

Akene he hiahia koe ki te whakamatautau BCR-ABL mena he tohu koe mo te leukemia myeloid roa (CML) me te Ph-positive leukemia lymphoblastic whakapau (KATOA). Kei roto i enei:

• Ngenge
• Fever
• Te whakaheke taumaha
• Te werawera o te po (te werawera nui i te wa e moe ana)
• Te mamae tahi, te wheua ranei

Ko etahi taangata whai CML, Ph-positive KATOA ranei kaore he tohu, he tohu tino ngawari ranei, ina koa i nga waahanga wawe o te mate. No reira ka ahei to kaiwhakarato hauora ki te tono i tenei whakamatautau mena ka whakahekehia te tatauranga toto katoa, o tetahi atu whakamatautau toto ranei, he hua ehara i te mea noa. Me whakamohio atu hoki ki to kaiwhakarato mena kei a koe etahi tohu e pa ana ki a koe. He maama ake te hamani i te CML me te Ph-positive KATOA ka kitea wawe.

Akene ka hiahiatia ano e koe tenei whakamatautau mena kei te tukuna koe mo CML, Ph-positive KATOA ranei. Ka taea e te whakamatautau te awhina i to kaiwhakarato kia kite mena kei te pai to maimoatanga.

Ka ahatia i te wa o te whakamatautau ira a BCR-ABL?

Ko te whakamātautau BCR-ABL he whakamātautau toto, he tikanga ranei e kiia ana ko te wawata o te wheua me te koiora koiora.

Mena kei te whakamatautauria to toto, ka tangohia e tetahi tohunga ngaio hauora tetahi tauira toto mai i te uaua i roto i to ringa, ma te whakamahi i te ngira iti. Whai muri i te kuhunga o te ngira, ka kohia he toto iti ki roto i te ipuipu, ipu ranei. Akene he iti to ngau ka puta te ngira ki waho ka puta atu ranei. Ko te tikanga ka iti ake i te rima meneti tenei.

Mena kei te whiwhi koe i te wawata wheua wheua me te koiora koiora, ko nga tikanga ka whai ake:

• Ka takoto koe i to taha, i to kopu ranei, ma tehea wheua e whakamahia hei whakamatautau. Ko te nuinga o nga whakamatautau wheua wheua ka tangohia i te wheua hope.
• Ka taupokina to tinana ki te kakahu, kia kitea noa ko te rohe huri noa i te waahi whakamatautau.
• Ka horoia te papaanga ki te rongoa antiseptic.
• Ka werohia koe i te rongoa koretake. Ka ngau pea.
• Kia koretake te rohe, ka tangohia e te kaiwhakaora hauora te tauira. Me takoto marie koe i nga wa o nga whakamatautau.
  • Mo te wawata o te wheua wheua, i te nuinga o te wa ka mahia i te tuatahi, ka whakauruhia e te kaiwhakarato hauora tetahi ngira ki roto i te koiwi ka toia mai te wai wheua wheua me nga kamera. Ka mamae pea koe engari ka paku te mamae ka whakauruhia ana te ngira.
  • Mo te koiora wheua wheua, ka whakamahia e te kaiwhakarato ratonga hauora tetahi taputapu motuhake ka huri ki roto ki te wheua hei tango i tetahi tauira kiko kiko wheua. Akene he pehanga kei runga i te papaanga i te wa e tangohia ana te tauira.
• 10 meneti pea te roa hei whakamana i nga whakamatautau e rua.
• Whai muri i te whakamātautau, ka hipokina e te kaiwhakaora hauora te papa ki te takai.
• Whakamaherehere kia tonoa koe e tetahi ki te kaainga, na te mea i tukuna ki a koe he kaiwhakamahu i mua o nga whakamatautau, kia hiamoe ai koe.

Me mahi e au tetahi mea hei whakareri mo te whakamatautau?

Te tikanga kaore e hiahiatia etahi whakaritenga motuhake mo te whakamatautau toto, wheua wheua ranei.

He raru pea mo te whakamatautau?

He iti noa te tuponotanga ka tirohia o toto. Ka mamae pea koe, ka maru ranei koe i te waahi i maka ai te ngira, engari ko te nuinga o nga tohu ka tere wawe.

Whai muri i te whakamatautau i te koiwi wheua, ka pakeke pea ka mamae koe i te waahi weronga ranei. Te tikanga ka haere tenei i roto i etahi ra. Ka tohu pea to kaiwhakarato hauora ki te whakahau ranei i tetahi kaitoha mamae ki te awhina.

He aha te tikanga o nga hua?

Mena ka whakaatu mai o kitenga kei a koe te ira BCR-ABL, me nga momo toto ma ma, kaore pea koe e mate i te mate myemiaid leukemia (CML) Ph-positive, leukemia lymphoblastic whakapau (KATOA).

Mena kei te tukuna koe mo CML, Ph-positive KATOA ranei, ka whakaatu pea o hua:

• Ko te rahinga o te BCR-ABL kei roto i to toto, toiwi wheua ranei kei te piki haere. Ko te tikanga pea kaore i te mahi to maimoatanga me / kua whakahee ranei koe i tetahi maimoatanga.
• Ko te rahinga o te BCR-ABL kei roto i to toto, i to kiri wheua ranei e heke ana. Ma te tikanga pea kei te pai to maimoatanga.
• Ko te rahinga o te BCR-ABL i roto i to toto, wheua wheua ranei kaore i piki ake, kua heke ranei. Ko te tikanga tenei kei te pumau to mate.

Mena he paatai ​​taau mo o hua, korero ki to kaiwhakarato hauora.

Ako atu mo nga whakamatautau taiwhanga, awhe tohutoro, me te maarama ki nga hua.

He mea ano me mohio au mo te whakamatautau ira a BCR-ABL?

Ko nga maimoatanga mo te leukemia myeloid tuuturu (CML) me te Ph-positive, leukemia lymphoblastic whakapau (KATOA) kua angitu ki nga tuuroro me enei momo reukemata. He mea nui kia kite i to kaiwhakarato hauora i nga waa katoa kia mohio kei te haere tonu o mahi maimoatanga. Mena kua pukuriri koe ki te rongoa, ka taunaki pea to kaiwhakarato i etahi atu momo rongoa mate pukupuku.

Tohutoro

1. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. He aha te take o te Leukemia Myeloid Ma'i [whakahoutia i te 2018 Jun 19; whakahuahia 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.org/cancer/chronic-myeloid-leukemia/causes-risks-prevention/what-causes.html
2. Cancer.net [Ipurangi]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Leukemia: Maamahi Myeloid: CML: Whakataki; 2018 Maehe [i whakahuahia i te 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/introduction
3. Cancer.net [Ipurangi]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Leukemia: Myeloid Ma'i: CML: Nga Maimoatanga Maimoatanga; 2018 Maehe [i whakahuahia i te 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/treatment-options
4. Nga Whakamatautau Reipa Aipurangi [Ipurangi]. Washington D.C: American Association mo te Haumanu Haumanu; c2001–2018. BCR-ABL1 [whakahoutia 2017 Tihema 4; whakahuahia 2018 Akuhata 1]; [tata ki te 2 nga mata]. Wātea mai i: https://labtestsonline.org/tests/bcr-abl1
5. Nga Whakamatautau Reipa Aipurangi [Ipurangi]. Washington D.C: American Association mo te Haumanu Haumanu; c2001–2018. Leukemia [whakahoutia 2018 Jan 18; whakahuahia 2018 Akuhata 1]; [tata ki te 2 nga mata]. Wātea mai i: https://labtestsonline.org/conditions/leukemia
6. Leukemia and Lymphoma Society [Ipurangi]. Rye Brook (NY): Leukemia me te Lymphoma Society; c2015. Chronic Myeloid Leukemia [whakahua i te 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: http://www.lls.org/leukemia/chronic-myeloid-leukemia
7. Mayo Clinic [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1998–2018. Te koiora koiora wheua me te wawata: Tirohanga; 2018 Jan 12 [i whakahuahia i te 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1998–2018. Leukemia myelogenous tuuturu: Tirohanga; 2016 Mei 26 [i whakahuahia i te 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.mayoclinic.org/diseases-conditions/chronic-myelogenous-leukemia/symptoms-causes/syc-20352417
9. Mayo Clinic: Mayo Medical Laboratories [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1995–2018. ID Whakamatautau: BADX: BCR / ABL1, Tohu Tika, Tohu Whakamatautau: Haumanu me te Whakamamaori [i whakahuahia i te 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89006
10. Merck Manual Kaihoko Putanga [Ipurangi]. Kenilworth (NJ): Merck & Co., Inc. c2018. Whakamatautau Iwi Tihi [whakahua i te 2018 Akuhata 1]; [tata ki te 2 nga mata]. Wātea mai i: http://www.merckmanuals.com/home/blood-disorder/symptoms-and-diagnosis-of-blood-disorder/bone-marrow-examination
11. Merck Manual Kaihoko Putanga [Ipurangi]. Kenilworth (NJ): Merck & Co., Inc. c2018. Chronic Myelogenous Leukemia [whakahua i te 2018 Akuhata 1]; [tata ki te 2 nga mata]. Wātea mai i: https://www.merckmanuals.com/home/blood-disorder/leukemias/chronic-myelogenous-leukemia
12. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Maimoatanga Myelogenous Leukemia Ma'i (PDQ®) -Tohu Putanga [whakahua i te 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq
13. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Nga Maimoatanga Mate Mate pukupuku kua Whakahauhia [i whakahuahia i te 2018 Akuhata 1]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
14. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Ture Mate Mate: BCR-ABL ira hono [i whakahuahia i te 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene
15. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Tikanga Mate Mate: BCR-ABL whakahiato putunga [kua whakahuahia i te 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-protein
16. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Whianga Mate Mate: ira [i whakahuahia i te 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
17. National Heart, Lung, and Blood Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Nga Whakatautau Toto [cited 2018 Aug 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.nhlbi.nih.gov/health-topics/blood-tests
18. NIH National Human Genome Research Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Nga Koretake o te Chromosome; 2016 Hanuere 6 [i whakahuahia i te 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.genome.gov/11508982
19. NIH U.S. National Library of Medicine: Genetics Home Tohunga [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. ABL1 ira; 2018 Jul 31 [faahitihia 2018 Aug 1]; [tata ki te 2 nga mata]. Wātea mai i: https://ghr.nlm.nih.gov/gene/ABL1#conditions
20. Oncolink [Ipurangi]. Philadelphia: Kaitiaki mo te Whare Waananga o Pennsylvania; c2018. Katoa Mo Nga Pakeke Maama Lymphocytic Leukemia (KATOA) [whakahoutia 2018 Hanu 22; whakahuahia 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai: https://www.oncolink.org/cancers/leukemia/leukemia-acute-lymphocytic-leukemia-all/all-about-adult-acute-lymphocytic-leukemia-all
21. Oncolink [Ipurangi]. Philadelphia: Kaitiaki mo te Whare Waananga o Pennsylvania; c2018. Katoa mo te Maama Myeloid Leukemia (CML) [whakahoutia 2017 Oketopa 11; whakahuahia 2018 Akuhata 1]; [tata ki te 3 nga mata]. Wātea mai i: https://www.oncolink.org/cancers/leukemia/chronic-myelogenous-leukemia-cml/all-about-chronic-myeloid-leukemia-cml

Ko nga korero kei tenei papaanga kaua e whakamahia hei whakakapi mo te tiaki ngaio ngaio, tohutohu ranei. Whakapa atu ki te kaiwhakarato hauora mena he paatai ​​taau mo to hauora.