Whakamatau Tuatahi BRAF

Toka Te Manawa

• He aha te whakamātautau ira BRAF?
• Hei aha te whakamahi?
• He aha i hiahiatia ai e ahau he whakamātautau ira BRAF?
• He aha te mahi i te wa o te whakamatautau ira a BRAF?
• Me mahi e au tetahi mea hei whakareri mo te whakamatautau?
• He raru pea mo te whakamatautau?
• He aha te tikanga o nga hua?
• He mea ano me mohio au mo te whakamatautau BRAF?
• Tohutoro

He aha te whakamātautau ira BRAF?

Ko te whakamatautau ira BRAF e rapu ana i tetahi whakarereketanga, e mohiotia ana ko te huringa, i roto i te ira e kiia ana ko BRAF. Ko te ira te waahanga taketake o te whakapapa i heke iho mai i to whaea me to papa.

Ma te ira BRAF e hanga he pūmua hei awhina i te tipu o te pūtau. E mohiotia ana ko te oncogene. He rite te oncogene ki te hiko hikoi i runga i te motuka. Te tikanga, ka huri te oncogene i te tipu tipu ina hiahiatia ana. Engari mena he rereketanga o te BRAF koe, he rite ki te piri o te penehi penehi, a kaore e taea e te ira te aukati i nga tipu kia tipu. Ko te tipu o te puoro kaore e taea te whakahaere ka pa te mate pukupuku.

Ka taea te tuku whakarereke BRAF mai i o matua ka riro mai i muri mai o to ao. Ko nga rereketanga ka tupu i muri ake o te koiora na te taiao i ahu mai i te he ranei ka puta i to tinana i te wa o te wehenga o te pūtau. He onge rawa te whakarereketanga o te BRAF kua riro, engari ka raru pea te hauora.

Whiwhi (e mohiotia ana ko somatic) Ko nga rereketanga BRAF he mea noa ake. Ko enei panoni kua kitea i te haurua o nga keehi katoa o te melanoma, te ahua kino rawa o te mate pukupuku kiri. Ko nga rereketanga BRAF he maha nga wa e kitea ana i etahi atu mate me nga momo mate pukupuku, tae atu ki nga mate pukupuku o te koroni, te tairoiro, me nga ovaries. Ko nga mate pukupuku me te rereketanga BRAF ka kaha ke atu i era kaore he panoni.

Othertahi atu ingoa: BRAF ira whakarerekētanga ira, Melanoma, BRAF V600 huringa, cobas

Hei aha te whakamahi?

I te nuinga o nga wa ka whakamahia te whakamatautau hei rapu i te rereketanga o te BRAF i nga tuuroro me te melanoma me etahi atu pukupuku pukupuku e pa ana ki te BRAF Ko etahi rongoa mate pukupuku e tino whaihua ana ki nga taangata e rere ke ana te BRAF. Ko nga rongoa pera kaore i te whai hua, i etahi wa ka kino ki nga taangata kaore he rereketanga.

Ka taea hoki te whakamatautau i te BRAF kia kite koe kei te tupono koe ki te mate pukupuku i runga i te hitori o te whanau me / to hitori hoki mo to hauora.

He aha i hiahiatia ai e ahau he whakamātautau ira BRAF?

Ka hiahia pea koe ki te whakamatautau i te BRAF mena kua tohua koe ki te melanoma, ki tetahi atu momo mate pukupuku ranei. Ma te mohio kei a koe te rereketanga ka taea e to kaiwhakarato te whakarite i te maimoatanga tika.

Akene me hiahia koe ki tenei whakamatautau kia kite koe kei teitei atu koe i te mate pukupuku. Ko nga mea morearea kei roto i te hitori o te mate pukupuku me / te mate pukupuku ranei i te wa e tamariki ana. Ko te tau motuhake e pa ana ki te momo mate pukupuku.

He aha te mahi i te wa o te whakamatautau ira a BRAF?

Ko te nuinga o nga whakamatautau BRAF ka mahia i roto i tetahi tikanga e kiia ana ko te koiora puku. I te wa e pa ana te koiora, ka tangohia e tetahi kaiwhakarato hauora tetahi waahanga iti ma te tapahi, ka pakaru ranei te mata o te pukupuku. Mena me whakamatautau e to kaiwhakarato te kiko puku i roto i to tinana, ka whakamahia pea e ia he ngira motuhake hei tango i te tauira.

Me mahi e au tetahi mea hei whakareri mo te whakamatautau?

Te tikanga kaore e hiahiatia etahi whakaritenga motuhake mo te whakamatautau BRAF.

He raru pea mo te whakamatautau?

Akene he iti to maru, he toto ranei kei te papa koiora. Akene he ahua iti pea to awangawanga ki te papaanga mo te rua rua ra ranei.

He aha te tikanga o nga hua?

Mena he melanoma koe tetahi atu momo mate pukupuku ranei, a ko nga hua ka kitea he rereketanga o te BRAF, ka taea e to kaiwhakarato te whakarite i nga rongoa kua hangaia hei tohu i te rereketanga. He pai ake te whai hua o enei rongoa i era atu maimoatanga.

Mena he melanoma koe tetahi atu momo mate pukupuku ranei, ka whakaatu nga hua ki a koe kaua e mahi he whakarereketanga, ka tohua e to kaiwhakarato nga momo rongoa hei whakaora i to mate pukupuku.

Mena kaore ano koe kia tohua he matepukupuku me te whakaatu i o hua kua puta ke koe i tetahi ira ira BRAF, kaore te tikanga he mate pukupuku koe, engari ka kaha ake to mate ki te mate pukupuku. Engari ko te tirotiro matepukupuku i nga wa katoa, penei i te whakamatautau kiri, ka taea te whakaiti i to tuponotanga. I te wa o te whakamātautau kiri, ka tirohia e te kaitoha hauora te kiri o to tinana katoa hei tirotiro i nga kiore me etahi atu whakatoihara.

Korero ki to kaiwhakarato mo etahi atu huarahi ka taea e koe hei whakaiti i to tuponotanga.

Ako atu mo nga whakamatautau taiwhanga, awhe tohutoro, me te maarama ki nga hua.

He mea ano me mohio au mo te whakamatautau BRAF?

Ka rongo pea koe i to kaiwhakarato e korero ana mo te rereketanga o te V600E. He rereke nga momo whakarereke BRAF. Ko te V600E te momo rereketanga o te BRAF.

Tohutoro

1. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. Melanoma Mate Mate Kiri; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.org/cancer/melanoma-skin-cancer.html
2. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. Nga ira oncogenes me te pehanga puku; [whakahoutia 2014 Jun 25; cited 2018 Jul 10]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
3. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. Maimoatanga Tutuki mo te Mate Mate Kiri o Melanoma; [whakahoutia 2018 Jun 28; cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
4. Mate pukupuku.Net [Ipurangi]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Whakamatau Whakamatau mo te Mate Mate Mate Mate 2017 Jul [whakahuaia 2018 Jul 10]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetic-testing-cancer-risk
5. Mate pukupuku.Net [Ipurangi]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Te Maarama ki te Maimoatanga Whaainga; 2018 Mei [whakahua 2018 Jul 10]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/ Understanding-targeted-therapy
6. Oncology Tuuturu [Ipurangi]. Laboratory Corporation o Amerika; c2018. BRAF Whakapakari Whakawhitinga Ira; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.integratedoncology.com/test-menu/braf-gene-mutation-analysis/07d322d7-33e3-480f-b900-1b3fd2b45f28
7. Nga Whakamatautau Reipa Aipurangi [Ipurangi]. Washington D.C: American Association mo te Haumanu Haumanu; c2001–2018. Biopsy; [whakahoutia 2017 Jul 10; cited 2018 Jul 10]; [tata ki te 2 nga mata]. Wātea mai i: https://labtestsonline.org/glossary/biopsy
8. Nga Whakamatautau Reipa Aipurangi [Ipurangi]. Washington D.C .: American Association mo te Haumanu Haumanu; c2001–2018. Nga Whakamatau Taketake mo te Maimoatanga Mate Mate pukupuku kua Whāia; [whakahoutia 2018 Jul 10; cited 2018 Jul 10]; [tata ki te 2 nga mata]. Wātea mai i: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
9. Mayo Clinic: Mayo Medical Laboratories [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1995–2018. ID Whakamatautau: BRAFT: BRAF Mutation Analysis (V600E), Tumor: Haumanu me te whakamaoritanga; [cited 2018 Jul 10]; [e 4 pea nga mata]. Wātea mai i: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
10. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Whakamatau Whakamatau mo nga Taane Mate Mate Mate; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
11. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Tikanga Mate Mate: ira BRAF; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
12. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Whianga Mate Mate: BRAF (V600E) whakarereke; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
13. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Tikanga Mate Mate: ira; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
14. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Tikanga Mate Mate: oncogene; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncogene
15. NIH U.S. National Library of Medicine: Genetics Home Tohunga [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Ira BRAF; 2018 Jul 3 [whakahua 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://ghr.nlm.nih.gov/gene/BRAF
16. NIH U.S. National Library of Medicine: Genetics Home Tohunga [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. He aha te hurihanga o te ira me te aha e puta ai nga rereketanga ?; 2018 Jul 3 [whakahua 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://ghr.nlm.nih.gov/primer/mutationsanddisorder/genemutation
17. Quest Diagnostics [Ipurangi]. Diagnostics Uiui; c2000–2017. Pokapū Whakamatau: Melanoma, BRAF V600 Mutation, Cobas: Aratohu whakamaori; [cited 2018 Jul 10]; [e 4 pea nga mata]. Wātea mai i: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
18. Quest Diagnostics [Ipurangi]. Diagnostics Uiui; c2000–2017. Pokapū Whakamatau: Melanoma, BRAF V600 Mutation, Cobas: Tirohanga Katoa; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90956
19. Whare Wananga o Rochester Medical Center [Ipurangi]. Rochester (NY): Whare Wananga o Rochester Medical Center; c2018. Encyclopedia Hauora: Melanoma: Maimoatanga Whāiti; [cited 2018 Jul 10]; [tata ki te 2 nga mata]. Wātea mai i: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=BMelT14
20. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Korero Hauora: Whakamatau Tinana o te Kiri mo te Mate Mate Kiri: Tirohanga Tirohanga; [whakahoutia 2017 Mei 3; cited 2018 Jul 18]; [tata ki te 2 nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
21. Hauora [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. He Korero Hauora: Kiri Mate, Melanoma: Kaupapa Arotake; [whakahoutia 2017 Mei 3; cited 2018 Jul 10]; [tata ki te 2 nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/major/skin-cancer-melanoma/hw206547.html
22. Hauora UW: Te Hohipera Tamariki Whanau Amerikana [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Hauora Tamariki: Biopsy; [cited 2018 Jul 10]; [tata ki te 3 nga mata]. Wātea mai i: https://www.uwhealthkids.org/kidshealth/en/father/biopsy.html/
23. Zial J, Hui P. BRAF whakamatau whakamatautau i nga mahi haumanu. Tohunga Rev Mol Diagn [Ipurangi]. 2012 Maehe [i whakahuahia i te 2018 Jul 10]; 12 (2): 127–38. Wātea mai i: https://www.ncbi.nlm.nih.gov/pubmed/22369373

Ko nga korero kei tenei papaanga kaua e whakamahia hei whakakapi mo te tiaki ngaio ngaio, tohutohu ranei. Whakapa atu ki te kaiwhakarato hauora mena he paatai ​​taau mo to hauora.