Te ngoikore o te antitrypsin Alpha-1

Ko te ngoikoretanga o te antitrypsin Alpha-1 (AAT) he ahuatanga e kore ai e nui te tinana o te tinana ki te AAT, he poroteini hei tiaki i nga huhu me te ate mai i te kino. Ko te ahuatanga ka arahi ki te COPD me te mate ate (cirrhosis).

Ko te AAT he momo momo poroteini e kiia ana he aukati protease. Ka mahia te AAT i roto i te ate ka mahi hei tiaki i nga huhu me te ate.

Ko te ngoikoretanga o te AAT kaore i te rahi noa iho te hinu i roto i te tinana. Na te ngoikoretanga o te whakapapa te take. Ko te ahuatanga e kaha kitea ana i waenga i nga Pakeha me nga Amerikana o te Raki o te Pakeha.

Ko nga pakeke e tino ngoikore ana ki te AAT ka whanakehia te mate wheysema, i etahi wa i mua i te 40 tau te pakeke. Ma te momi hikareti e piki ai te tuponotanga o te mate urupare ka puta wawe atu.

Kei roto i nga tohu nga tohu e whai ake nei:

• Te manawa poto me te kore e whakapau kaha, me etahi atu tohu o te COPD
• Tohumate o te ngoikore o te ate
• Ngaronga o te taumaha me te kore e tarai
• Wheezing

Ma te tirotirohanga a-tinana e whakaatu mai he pouaka e rite ana ki te oko, e pupuhi ana, e heke ana ranei te tangi o te manawa. Ko nga whakamatautau e whai ake nei ka awhina pea i te tohu mate:

• Whakamatautau toto AAT
• Ko nga haurangi toto whakaheke toto
• Papa-hihi
• Karapa CT o te pouaka
• Whakamatau ira
• Whakamātautau mahi paru

Ka whakapae pea to kaiwhakarato hauora kei a koe tenei mate mena ka whanake koe:

• COPD i mua i te 45 tau
• COPD engari kaore ano koe kia kai paipa, kaore ano koe i paku paitini
• COPD a he hitori o to whanau to ahuatanga
• Ko te Cirrhosis kaore ano kia kitea tetahi atu take
• Ko te Cirrhosis me to whanau he mate ate

Ko te maimoatanga mo te ngoikoretanga AAT ko te whakakapi i te pūmua AAT kua ngaro. Ka tukuna te pūmua mā te uaua i ia wiki, ia wiki 4 ranei. He paku noa tenei e aarai ana ki te aukati i te kino atu o te huhu ki te hunga kaore he mate mutunga-mutunga. Ko tenei mahinga e kiia ana ko te haumanu whakaniko.

Mena ka paowa koe, me mutu.

Ko etahi atu maimoatanga ka whakamahia mo te COPD me te cirrhosis.

Ka taea te tango i te paru mo te mate pukupuku tino mate, a ka taea te tango i te ate mo te cirrhosis kino.

Ko etahi taangata e ngoikore ana tenei kaore e pa he mate ate, mate huka ranei. Ki te whakamutu koe i te momi hikareti, ka taea e koe te whakaheke i te haere whakamua o te mate mama.

Ko te COPD me te cirrhosis he mea morearea ki te ora.

Ko nga raru o te ngoikoretanga AAT ko:

• Bronchiectasis (he kino ki nga ara nui)
• Ma'i mate pehanga aukati (COPD)
• Te ngoikore o te ate, te pukupuku ranei

Whakapa atu ki to kaiwhakarato ki te whakawhanakehia e koe nga tohu o te ngoikoretanga AAT.

Ngoikoretanga AAT; Te ngoikore o te protease Arepa-1; COPD - alpha-1 antitrypsin ngoikoretanga; Cirrhosis - alpha-1 antitrypsin deficience

• Pakihi
• Anatomia ate

Han MK, Raharuhi SC. COPD: taatai ​​haumanu me te whakahaere. I roto i: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Pukapuka Whakaakoranga a Murray me Nadel mo te Whakaoranga Hauora. 6 ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 44.

Hatipoglu U, Stoller JK. a1 -antitrypsin ngoikoretanga. Clin Chest Med. 2016; 37 (3): 487-504. PMID: 27514595 www.pubmed.ncbi.nlm.nih.gov/27514595/.

Winnie GB, Boas SR. a1 -antitrypsin ngoikoretanga me te mate urupare. I roto i: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Pukapuka Pukapuka a Whakatata mo nga Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chap 421.