PDL1 (Immunotherapy) Nga Whakamatau

Toka Te Manawa

• He aha te whakamatautau PDL1?
• Hei aha te whakamahi?
• He aha i hiahiatia ai e au he whakamatautau PDL1?
• Ka ahatia i te wa o te whakamatautau PDL1?
• Me mahi e au tetahi mea hei whakareri mo te whakamatautau?
• He raru pea mo te whakamatautau?
• He aha te tikanga o nga hua?
• He mea ano me mohio au mo te whakamatautau PDL1?
• Tohutoro

He aha te whakamatautau PDL1?

Ko tenei whakamatautau ka whanganga i te nui o PDL1 kei runga i nga pukupuku pukupuku. Ko te PDL1 he pūmua hei awhina i nga kiriuhi ki te whakaeke i nga puoro kore kino o te tinana. Te tikanga, ko te punaha mate e whawhai ana ki nga matū o tawahi penei i nga wheori me nga kitakita, kaore ko o raau ake hauora. Ko etahi o nga pukupuku pukupuku he nui te PDL1. Ma tenei ka taea e nga pukupuku pukupuku te "tinihanga" i te punaha aukati, me te aukati i te whakaekehia hei manene, he matū kino.

Mena he nui te nui o te PDL1 i o pukupuku pukupuku, ka whai hua koe mai i te maimoatanga e kiia ana ko te immunotherapy. Ko te Immunotherapy he whakamaimoa e whakanui ana i to punaha aarai mate kia pai ai tona mohio ki te whawhai ki nga pukupuku pukupuku. Ko te Immunotherapy kua kitea he tino whaihua mo te whakaora i etahi momo mate pukupuku. Ka iti ake pea nga paanga o te taha i era atu rongoa mate pukupuku.

Othertahi atu ingoa: programme te mate-ligand 1, PD-LI, PDL-1 na te urupare-mate (IHC)

Hei aha te whakamahi?

Whakamahia ai te whakamātautau PDL1 kia kite koe mena he mate pukupuku koe ka whai hua koe mai i te kano kano mate.

He aha i hiahiatia ai e au he whakamatautau PDL1?

Ka hiahia pea koe ki te whakamatautau PDL1 mena kua kitea e koe tetahi o nga mate pukupuku e whai ake nei:

• Te mate pukupuku roro kore-iti
• Melanoma
• Hodgkin lymphoma
• Mate matepukupuku
• Matepukupuku tākihi
• Mate pukupuku pukupuku

Ko nga taumata tiketike o te PDL1 e kitea ana i enei wa, me etahi atu momo mate pukupuku. Ko nga mate pukupuku e kaha ana te nui o te PDL1 ka taea te whakaora totika ma te mate kano mate.

Ka ahatia i te wa o te whakamatautau PDL1?

Ko te nuinga o nga whakamatautau PDL1 ka mahia i tetahi waahanga e kiia ana ko te koiora. E toru nga momo tikanga koiora matua:

• Te koiora koiora koiora koiora, e whakamahi ana i te ngira tino angiangi hei tango i tetahi tauira o nga puoro, i te wai ranei
• Biopsy ngira matua, e whakamahi ana i te ngira rahi ake hei tango tauira
• Haurongo taatai, e tango ana i tetahi tauira i roto i te tikanga iti, i te tūroro tūroro

Ko te wawata ngira pai me te koiora koi ngira matua te tikanga ko nga mahi e whai ake nei:

• Ka takoto koe ki to taha ka noho ranei i runga i te teepu whakamātautau.
• Ma te kaiwhakarato hauora e horoi i te papaa koiora ka werohia ki te rongoa rongoa kia kore ai koe e mamae i te wa o te mahinga.
• Ka pore noa te rohe, ka whakauruhia e te kaiwhakarato he ngira wawata pai te ngira koiora koiora ranei ki te waahi koiora ka tango i tetahi tauira kiko, waikore ranei.
• Akene he iti ake te pehanga i a koe ka tangohia ana te tauira.
• Ka tukuna te peehi ki te waahi koiora kia mutu ra ano te toto.
• Ka tohaina e to kaiwhakarato he takai taatai ​​i te waahi koiora.

I roto i te waahanga koiora, ka tapahia e tetahi taote tipua he kiri iti ki to kiri kia tangohia katoa, tetahi waahanga ranei o te puoro u. I etahi wa ka mahia he koiora pokanga mena kaare e tae te puranga ki te koiora ngira. Ko nga tikanga biopsies taatai ​​e whai ake nei.

• Ka takoto koe i runga i te teepu whakahaere. He IV (raina haurangi) ka tuu pea ki to ringa, ki to ringa ranei.
• Ka whakawhiwhia pea ki a koe te rongoa, e kiia ana he kaiwhakamarie, kia pai ai to noho.
• Ka whakawhiwhia koe ki te rongoa kaainga a rohe, whanui ranei kia kore ai koe e mamae i te waa o te mahinga.
  • Mo te mate rongoa o te rohe, ka werohia e te kaiwhakarato ratonga hauora te papa koiora ki te rongoa mo te rohe.
  • Mo te mate rongoa whaanui, ma te tohunga i huaina ko te tohunga rongoa rongoa ka hoatu he rongoa ki a koe kia kore ai koe e mohio i nga wa o te mahinga.
• Ka koretake te waahanga koiora, kaore koe i te mohio ranei, ka tapahia e te taote taatai ​​te tapahanga iti ki roto i te u, ka tangohia tetahi waahanga, tetahi waahanga ranei. Ka tangohia pea etahi kiko huri noa i te puranga.
• Ko te motu i roto i to kiri ka katihia ki te tuitui, ki te takai piripiri ranei.

He rereke nga momo koiora. Ko te momo koiora ka whiwhi koe ka whakawhirinaki ki te waahi me te rahinga o to puku.

Me mahi e au tetahi mea hei whakareri mo te whakamatautau?

Kaore koe e hiahia i etahi whakaritenga motuhake mena kei te whiwhi koe i te rongoa haumanu a te rohe (te whakamoe i te papaa koiora). Mena kei te whiwhi koe i te mate rongoa mate, akene me tere te nohopuku (kaua e kai, inu ranei) mo etahi haora i mua o te pokanga. Ma to taakuta tipua e tohutohu ake. Ano hoki, mena kei te whiwhi koe i te rongoa rongoa rongoa rongoa, mate rongoa whanui ranei, tirohia me whakarite kia taraihia koe e tetahi ki te kaainga. Akene he pukuriri koe ka poraruraru i muri i to ara mai i te mahinga.

He raru pea mo te whakamatautau?

Akene he iti to maru, he toto ranei kei te papa koiora. I etahi wa ka pangia te papaanga. Mena ka peena, ka tukuna koe ki nga antibiotic. Ma te koi biopsy e mate ai etahi atu mamae me te kore e ngakau mamae. Ka taunaki pea to kaiwhakarato hauora ki te whakahau ranei i nga rongoa hei awhina i a koe ki te pai.

He aha te tikanga o nga hua?

Mena ka whakaatu o hua i o pukupuku pukupuku he nui te nui o te PDL1, akene ka tiimata koe mo te kano kano mate. Ki te kore e whakaatu o hua tiketike i te nui o te PDL1, akene pea kaore e whai hua te mate aukati ki a koe. Engari ka whai hua koe mai i tetahi atu momo maimoatanga mate pukupuku. Mena he paatai ​​taau mo o hua, korero ki to kaiwhakarato hauora.

Ako atu mo nga whakamatautau taiwhanga, awhe tohutoro, me te maarama ki nga hua.

He mea ano me mohio au mo te whakamatautau PDL1?

Kaore te Immunotherapy e mahi mo te katoa, ahakoa he pukupuku koe me te nui o te PDL1. He uaua nga pukupuku pukupuku, he maha tonu kaore e mohiotia. Kei te ako tonu nga kaiwhakarato hauora me nga kairangahau e pa ana ki te aukati mate mate me te tohu ko wai ka whai hua mai i tenei maimoatanga.

Tohutoro

1. Hauora Allina [Ipurangi]. Minneapolis: Hauora Allina; c2018. Immunotherapy mo te mate pukupuku; [cited 2018 Aug 14]; [tata ki te 3 nga mata]. Wātea mai i: https://wellness.allinahealth.org/library/content/60/903
2. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. Nga kaiwhakawhiwhi tohu arai mate mate ki te whakaora mate pukupuku; [whakahoutia 2017 Mei 1; whakahuahia 2018 Akuhata 14]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/immune-checkpoint-inhibitors.html
3. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. He Aha Te Maimoatanga Mate Mate pukupuku e Tuturu ana ?; [whakahoutia 2016 Jun 6; whakahuahia 2018 Akuhata 14]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/targeted-therapy/what-is.html
4. American Cancer Society [Ipurangi]. Atlanta: American Cancer Society Inc. c2018. He aha nga mea hou o te rangahau mate pukupuku mate pukupuku ?; [whakahoutia 2017 Oketopa 31; whakahuahia 2018 Akuhata 14]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/whats-new-in-immunotherapy-research.html
5. Mate pukupuku.Net [Ipurangi]. Alexandria (VA): American Society of Clinical Oncology; c2005-–2018. 9 Nga Mea e mohio Ana Mo Te Mate Mate Mate me te Mate Mate pukupuku; 2016 Nov 8 [whakahuaia 2018 Akuh 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.net/blog/2016-11/9-things- know-about-immunotherapy-and-lung-cancer
6. Dana-Farber Cancer Institute [Ipurangi]. Boston: Institute-Mate Mate Mate Mate; c2018. He aha te Whakamātautau PDL-1 ?; 2017 Mei 22 [whakahoutia 2017 Jun 23; whakahuahia 2018 Akuhata 14]; [tata ki te 3 nga mata]. Wātea mai i: https://blog.dana-farber.org/insight/2017/05/what-is-a-pd-l1-test
7. Oncology Tuuturu [Ipurangi]. Laboratory Corporation o Amerika, c2018. PDL1-1 na IHC, Opdivo; [cited 2018 Aug 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.integratedoncology.com/test-menu/pd-l1-by-ihc-opdivo%C2%AE/cec2cfcc-c365-4e90-8b79-3722568d5700
8. Nga Whakamatautau Reipa Aipurangi [Ipurangi]. Washington D.C .: American Association mo te Haumanu Haumanu; c2001–2018. Nga Whakamatau Taketake mo te Maimoatanga Mate Mate pukupuku kua Whāia; [whakahoutia 2018 Jun 18; whakahuahia 2018 Akuhata 14]; [tata ki te 2 nga mata]. Wātea mai i: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
9. Mayo Clinic: Mayo Medical Laboratories [Ipurangi]. Mayo Foundation mo te Whakaakoranga Hauora me te Rangahau; c1995–2018. ID Whakamatautau: PDL1: Kua Whakamahuahia te Mate-Ligand 1 (PD-L1) (SP263), Semi-Quantitative Immunohistochemistry, Manual: Haumanu me te whakamaoritanga; [cited 2018 Aug 14]; [e 4 pea nga mata]. Wātea mai i: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/71468
10. MD Anderson Te Whare Mate Mate [Ipurangi]. Te Whare Waananga o Texas MD Anderson Te Whare Mate Mate; c2018. Ma tenei kitenga ka whakapiki ake i te whai hua o te paatai ​​mate pukupuku; 2016 Sep 7 [faahitihia 2018 Aug 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.mdanderson.org/publications/cancer-frontline/2016/09/discovery-may-increase-immunotherapy-effectiveness.html
11. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. NCI Papakupu mo nga Tikanga Mate Mate: mate whakaora; [cited 2018 Aug 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/immunotherap
12. National Cancer Institute [Ipurangi]. Bethesda (MD): Te Tari Hauora me nga Ratonga Tangata a U.S. Tohu Tumor; [cited 2018 Aug 14]; [e 4 pea nga mata]. Wātea mai i: https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet
13. Te Poari Mate Matapihi Katoa o Sydney Kimmel [Ipurangi]. Baltimore: Te Whare Wananga o Johns Hopkins; Nga Take o te Uma: Te Whakatupato i te Mate Hauora mo te Mate Mate pukupuku; [cited 2018 Aug 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.hopkinsmedicine.org/news/publications/breast_matters/files/sebindoc/a/p/ca4831b326e7b9ff7ac4b8f6e0cea8ba.pdf
14. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Korero Hauora: Punaha Immune; [whakahoutia 2017 Oketopa 9; whakahuahia 2018 Akuhata 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.uwhealth.org/health/topic/ConditionCenter/Immune%20System/center1024.html
15. Hauora UW [Ipurangi]. Madison (WI): Te Whare Waananga o Wisconsin Whare Hauora me te Mana Haumanu; c2018. Panui me nga Takahanga: Te Whakaako i te Punaha Kaha ki te Whawhai i te Mate Mate pukupuku; [whakahoutia 2017 Akuhata 7; whakahuahia 2018 Akuhata 14]; [tata ki te 3 nga mata]. Wātea mai i: https://www.uwhealth.org/news/the-immune-system-goes-to-school-to-learn-how-to-fight-cancer/51234

Ko nga korero kei tenei papaanga kaua e whakamahia hei whakakapi mo te tiaki ngaio ngaio, tohutohu ranei. Whakapa atu ki te kaiwhakarato hauora mena he paatai ​​taau mo to hauora.